Longevity Intervention Database


Database Top list ITP ITP (females) ITP (males)
Top list
longevity interventions		 Rats
Strain F344		 Rats
Other strains		 Mice
Strain HET3		 Mice
Strain C57BL6		 Mice
Other strains		 Fruit flies
Strain Canton S		 Roundworms
Strain N2		 Roundworms
Other strains
Calorie restriction

Median lifespan:

Maximum lifespan:

 

19%

 

26%

 

13%

 

26%

40%

39%

39%

27%

 

35%

 

16%

65%

42%

51%

24%

 

 

 

 

 

 

 

 

Rapamycin

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

28%

22%

21%

11%

7%

14%

19%

8%

77%

17%

117%

18%

12%

14%

7%

5%

27%

25%

11%

11%

Rapamycin + Acarbose

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

28%

37%

21%

24%

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Doxycycline

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

29%

34%

35%

39%

95%

84%

 

 

Metformin + Rapamycin

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

23%

23%

17%

10%

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Maximum lifespan:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

744%

748%

Maximum lifespan:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

686%

748%

Metformin

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

0%

7%

0%

-1%

 

9%

 

0%

 

 

 

 

27%

30%

32%

34%

41%

57%

35%

15%

Rifampicin

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

22%

45%

20%

31%

85%

78%

 

 

Captopril

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

5%

14%

8%

7%

 

 

 

 

 

 

 

 

 

 

 

 

48%

46%

 

 

Acarbose

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

5%

22%

8%

12%

 

 

 

 

 

 

 

 

 

 

 

 

30%

7%

11%

5%

Canagliflozin

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

1%

14%

4%

10%

 

 

 

 

 

 

 

 

 

 

 

 

21%

45%

 

 

Resveratrol

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

4%

7%

3%

2%

 

 

 

 

 

 

 

 

 

 

 

 

85%

79%

84%

77%

daf-2 + rsks-1

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

464%

529%

Celecoxib + cyc-1 RNAi

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

78%

106%

 

 

Simvastatin

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

4%

4%

4%

3%

 

 

 

 

 

 

 

 

 

 

 

 

68%

51%

 

 

GSK2126458 + Doxycycline

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

109%

102%

 

 

17-a-estradiol

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

2%

19%

0%

12%

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Protandim

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

3%

7%

6%

6%

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

daf-2 + rsks-1 + glp-1(gf)

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

310%

356%